BIOMEDICINE: Brittle Bones

Syndromes with congenital brittle bones

BACKGROUND There is no clear definition of osteogenesis imperfecta (OI). The most widely used classification of OI divides the disease in four types, although it has been suggested that there may be at least 12 forms of OI. These forms have been named with numbers, eponyms or descriptive names. Some of these syndromes can actually be considered congenital forms of brittle bones resembling OI (S...

Material Properties of Brittle Bones

INTRODUCTION Osteogenesis imperfecta (OI) is a genetic disorder of type I collagen that results in bone fragility. This fragility is believed to stem from a combination of bone mass deficiency and compromised bone material properties [13]. Little data, however, is yet available to describe bone material properties in individuals with OI. This study presents the first characterization of bone ma...

Brittle Bones, Unbreakable Spirit: Osteogenesis Imperfecta

Address for Correspondence: Dr. Subhra Mandal, Associate Professor, Dept. of Anatomy, Medical College Kolkata, West Bengal , India. Contact No.: +919477458100 E-Mail: [email protected] *1 Associate Professor, Dept. of Anatomy, Medical College Kolkata , West Bengal , India. 2 Post Graduate Resident in DNB (PMR), S.N.P. Hospital , Kolkata , West Bengal, India. 3 Professor & MSVP, Bankura Sa...

A Roadmap to the Brittle Bones of Cystic Fibrosis

Cystic fibrosis (CF) is an autosomal recessive disorder which despite advances in medical care continues to be a life-limiting and often fatal disease. With increase in life expectancy of the CF population, bone disease has emerged as a common complication. Unlike the osteoporosis seen in postmenopausal population, bone disease in CF begins at a young age and is associated with significant morb...

Brittle Bones: Osteoporosis and the Battery Cage A report for Compassion in World Farming